Pubblicazioni
Home > News > Pubblicazioni
Ferruzzi P., Mennillo F., De Rosa A., Giordani C., Rossi M., Benedetti G., Magrini R., Pericot Mohr G., Miragliotta V., Magnoni L., Mori E., Thomas R., Tunici P., Bakker A.
(2011)"In Vitro and In Vivo Characterisation of a Novel Hedgehog Signalling Antagonist in Human Glioblastoma Cell Lines", Int. J. Cancer, 20 Dec 2011, Epub ahead of print
Zanelli U., Caradonna N.P., Hallifax D., Turlizzi E., Houston B.J
(2011)" Comparson of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs", Drug Metab Dispos., 13 Oct 2011, Epub ahead of print
Gaviraghi M., Tunici P., Valensin S., Rossi M., Giordano C., Magnoni L., Dandrea M., Montagna L, Ritelli R., Scarpa A., Bakker A.
(2011)"Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells" Biosci Rep. (2011), 31 45-55.
Rossini L., Gianfriddo M., Scali C., Roncarati R., Franceschini D., Pollio G., Terstappen G.C., matsuoka M., Caricasole A.
(2011)" VTSML2 is a novel secreted antagonist of the neuroprotective peptide Humanin", FASEB J (2011) ,25 (6), 1983-2000
Rossi M., Magnoni L., Mori E., Bakker A.,Tini P., Tosi P., Oliveri G., Cosci E., Pirtoli L, Miracco C.
(2011)"beta-catenin and Gli1 as prognostic markers in glioblastoma multiforme", Cancer Biol Ther. (2011), 11(8), 753-61
Marquis K.L., Comery T.A., Jow F. , Navarra R.L., Grauer S.M. , Pulicicchio C., Kelley C., Roncarati R., Scali C., Haydar S., Ghiron C., Harrison B., Terstappen G.C, Dunlop J.
(2011) "Preclinical Assessment of an Adjunctive Treatment Approach for Cognitive Impairment Associated with Schizophrenia Using the Alpha7 Nicotinic Acetylcholine Receptor Agonist WYE-103914" Psychopharmacology (Berl.),218(4), 635-47 (2011)
Del Bello, Fabio; Mattioli, Laura; Ghelfi, Francesca; Giannella, Mario; Piergentili, Alessandro; Quaglia, Wilma; Cardinaletti, Claudia; Perfumi, Marina; Thomas, Russell J.; Zanelli, Ugo; Marchioro, Carla; Dal Cin, Michele; Pigini, Maria
(2010)Fruitful Adrenergic α 2C-Agonism/ α 2A-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence. Journal of Medicinal Chemistry (2010), 53(21), 7825-7835
Gaviraghi, Giovanni
(2010)ß -adrenoceptor agonists and asthma. Analogue-Based Drug Discovery II (2010), 319-331
Robertson G
(2010):Towards a more robust approach to selecting and prosecuting promising targets and compounds. Future Medicinal Chemistry (2010), 2(1), 25-34
Cocconcelli G, Ghiron C, Haydar S, Micco I, Zanaletti R
(2010): Synthesis of Novel 4-Fluoro-2H-pyrazol-3-ylamines. Synthetic Communications (2010), 40(17), 2547-2555.
Galvagni F, Pennacchini S, Salameh A, Rocchigiani M, Neri F, Orlandini M, Petraglia F, Gotta S, Sardone GL, Matteucci G, Terstappen GC, Oliviero S
(2010):Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src-Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity; Circulation Research (2010), 106, 1839-1848
Terstappen, GC, Roncarati R; Dunlop J; Peri R
(2010): Screening technologies for ion channel drug discovery. Future Medicinal Chemistry (2010), 2(5), 715-730.
Ghiron C, Haydar SN, Aschmies S, Bothmann H, Castaldo C, Cocconcelli G, Comery TA, Di L, Dunlop J, Lock T, Kramer A, Kowal D, Jow F, Grauer S, Harrison B, La Rosa S, Maccari L, Marquis KL, Micco I, Nencini A, Quinn J, Robichaud AJ, Roncarati R, Scali C, Terstappen GC, Turlizzi E, Valacchi M, Varrone M, Zanaletti R, Zanelli U.
(2010):Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914), Journal of medicinal chemistry Vol. 53 (11): 4379-89
Andersen, Claus A.; Rost, Burkhard
(2009)Secondary structure assignment. Structural Bioinformatics (2nd Edition) (2009), 459-484.
Bakker, A., Caricasole, A., Gaviraghi, G., Pollio, G., Robertson, G., Terstappen, G. C., Salerno, M. and Tunici, P.
(2009): How to achieve confidence in drug discovery and development: managing risk (from a reductionist to a holistic approach), ChemMedChem 4, 923-933
Andersen, C. A., Gotta, S., Magnoni, L., Raggiaschi, R., Kremer, A. and Terstappen, G. C.
(2009): Robust MS quantification method for phosphopeptides using 18O/16O labeling, BMC Bioinformatics 10, 141-156
Palmer, M., Kremer, A. and Terstappen, G. C.
(2009): A primer on screening data management, J. Biomol. Sciences, July 30 [Epub ahead of print]
Fecke, W., Gianfriddo, M., Gaviraghi, G., Terstappen, G. C. and Heitz, F.
(2009): Small molecule drug discovery for Huntington's disease, Drug Discovery Today 14, 453-464
Terstappen, G. C.
(2009):Not a dilemma: Target deconvolution in drug discovery,
Future Medicinal Chemistry , 1, 7-9
Tarditi, A., Caricasole, A. and Terstappen, G. C.
(2009):Therapeutic targets for Alzheimer's disease,
Expert Opinion on Therapeutic Targets , Apr 15 [Epub ahead of print]
Roncarati R., Scali C., Comery TA., Grauer SM., Achmies S., Bothmann H., Jow B., Kowal D., Gianfriddo M., Kelley C., Zanelli U., Ghiron C., Haydar S., Dunlop J., Terstappen, G. C.
(2009):Procognitive and neuroprotective activity of a novel class of alpha7 nicotinic acetylcholine receptor agonists for treatment of neurodegenerative and cognitive disorders
Journal of Pharmacology and Experimental Therapeutics, (epub ahead of print)
Valensin, S., Ghiron, C., Lamanna, C., Kremer, A., Rossi, M., Ferruzzi, P., Nievo, M. and Bakker, A.
(2009):KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain? BMC Cancer 9, 196
Rosi, M. C., Luccarini, I., Grossi, C., Fiorentini, A., Spillantini, M. G., Goedert, M., Prisco, A., Caricasole, A., Terstappen, G. C. and Casamenti, F.
(2009):Increased Dickkopf -1 expression in transgenic mouse models of neurodegenerative disease, J. Neurochem. (Dec 29 [Epub ahead of print])
Pasquini, S., Mugnaini, C., Brizzi, A., Ligresti, A., Di Marzo, V., Ghiron, C. and Corelli F.
(2009):Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N-alkylacetamides as CB2 receptor ligands, J. Comb. Chem. 11, 795-798
Millucci, L., Raggiaschi, R., Franceschini, D., Terstappen, G. C. and Santucci, A.
(2009):Rapid aggregation and assembly in aqueous solution of Aß (25-35) peptide, J. Biosci. 34, 293-303
Mastroiacovo, F., Busceti, C.L., Biagioni, F., Moyanova, S.G., Meisler, M.H., Battaglia, G., Caricasole, A., Bruno, V. and Nicoletti, F.
(2009):Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia, J. Cereb. Blood Flow Metab. 29, 264-76
Haydar, S.N., Ghiron, C., Bettinetti, L., Bothmann, H., Comery, T.A., Dunlop, J., La Rosa, S., Micco, I., Pollastrini, M., Quinn, J., Roncarati, R., Scali, C., Valacchi, M., Varrone, M. and Zanaletti, R.
(2009):SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist, Bioorg. Med. Chem. 17, 5247-5258
Fantini, M., Rivara, M., Zuliani, V., Kalmar, C.L., Vacondio, F., Silva, C., Baheti, A.R., Singh,N., Merrick, E.C., Katari, R.S., Cocconcelli, G., Ghiron, C., Patel, M.K.
(2009):2,4(5)-diarylimidazoles as inhibitors of hNaV1.2 sodium channels: pharmacological evaluation and structure-property relationships, Bioorg. Med. Chem. 17, 3642-3648
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti F.
The Wnt Antagonist, Dickkopf-1, as a Target for the Treatment of Neurodegenerative Disorders.
Neurochem Res., 2008,33(12):2401-6, Apr 22
Heitz F., La Rosa S., Gonzalez-Couto E., Gaviraghi G. and Terstappen G. C.
Drug discovery and development for Huntington’s disease – an orphan indication with high medical need
IDrugs, 2008, 11, 653-660
Seredenina T., Ferraro T., Terstappen G.C., Caricasole A., Roncarati R.
Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors.
Biosci Rep. 2008 Aug 11.
Piras L., Genesio E., Ghiron C., Taddei M.
Scaffold Preparation and Parallel Synthesis of Arrays of 5,6,7,8-Tetrahydropyrrolo-azepinones in the Solution Phase
Eur. J. Org. Chem., 2008, 2789–2800
Micco I., Nencini A., Quinn J., Bothmann H., Ghiron C., Padova A., Papini S.
Parallel synthesis of a series of potentially brain penetrant aminoalkyl benzoimidazoles.
Bioorg Med Chem. 2008, 16, 2313-28
Cocconcelli G., Diodato E., Caricasole A., Gaviraghi G., Genesio E., Ghiron C., Magnoni L., Pecchioli E., Plazzib P.V. and Terstappen G.C.
Aryl azoles with neuroprotective activity—Parallel synthesis and attempts at target identification
Bioorg Med Chem 2008, 16, 2043-52
Pollio G., Hoozemans J.J., Andersen CA, Roncarati R, Rosi MC, van Haastert ES, Seredenina T, Diamanti D, Gotta S, Fiorentini A., Magnoni L., Raggiaschi R., Rozemuller A.J., Casamenti F., Caricasole A., Terstappen G.C.
Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity
Neurobiol Dis. 2008, 31, 145-58.
Pollio G., Roncarati R., Seredenina T., Terstappen G.C., Caricasole A.
A reporter assay for target validation in primary neuronal cultures
J Neurosci Methods. 2008, 172, 34-7.
Roncarati R., Seredenina T., Jow B., Jow F., Papini S., Kramer A., Bothmann H., Dunlop J., Terstappen G.C..
Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line.
Assay Drug Dev Technol. 2008, 6, 181-93.
Lamanna C., Bellini M., Padova A., Westerberg G., Maccari L.
Straightforward recursive partitioning model for discarding insoluble compounds in the drug discovery process.
J Med Chem. 2008, 51, 2891-7
Bernocco S., Fondelli C., Matteoni S., Magnoni L., Gotta S., Terstappen G.C., Raggiaschi R.
Sequential detergent fractionation of primary neurons for proteomics studies.
Proteomics, 2008, 8, 930-8.
Piras L., Ghiron C., Minetto G., Taddei M.
Microwave-assisted synthesis of tetrahydroindoles
Tetrahedron Letters, 2008, 49, 459–462
Terstappen, G.C.
Understanding Alzheimer’s disease.
Next Generation Pharmaceutical, 2007, 51-53
Terstappen G.C., Schlüpen C., Raggiaschi R., Gaviraghi G.
Target deconvolution strategies in drug discovery.
Nat Rev Drug Discov. 2007, 6, 891-903.
Dunlop, J., Roncarati, R., Jow, B., Bothmann, H., Lock, T., Kowal, D., Bowlby, M. and Terstappen, G. C.
In vitro screening strategies for nicotinic receptor ligands.
Biochem. Pharmacol. 2007, 74, 1172-1181
Gonzalez Couto E., Matteoni S., Gotta S., Magnoni L., Heitz F., Raggiaschi R., Terstappen G.C. and Kremer A.
Huntington’s Disease: From Experimental Results to Interaction Networks, Patho-Pathway Construction and Disease Hypothesis.
BMC Systems Biology, 2007, 1, 45
Zuliani V., Cocconcelli G., Fantini M., Ghiron C., Rivara M.
A practical synthesis of 2,4(5)-diarylimidazoles from simple building blocks.
J Org Chem. 2007, 72, 4551-3.
Piergentili A., Del Bello F., Gentili F., Giannella M., Quaglia W., Vesprini C., Thomas RJ and Robertson GM.
Solution-phase synthesis of ICG-001, a b-turn peptidomimetic molecule inhibitor of β-catenin–TCF-mediated transcription.
Tetrahedron. 2007, 63, 12912–12916
Magrini R., Bakker A., Gaviraghi G. and Terstappen G.C.
Targeting the p53 tumor suppressor gene function in glioblastomas using small chemical molecules.
Drug Development Research 2006, 67, 790-800
Scali C., Caraci F., Gianfriddo M., Diodato E., Roncarati R., Pollio G., Gaviraghi G., Copani A., Nicoletti F., Terstappen G.C., Caricasole A.
Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.
Neurobiol Dis. 2006, 24, 254-65
Caruso A., Motolese M., Iacovelli L., Caraci F., Copani A., Nicoletti F., Terstappen G.C., Gaviraghi G., Caricasole A.
Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.
J Neurochem. 2006, 98, 364-71.
Raggiaschi R., Lorenzetto C., Diodato E., Caricasole A., Gotta S., Terstappen G.C.
Detection of phosphorylation patterns in rat cortical neurons by combining phosphatase treatment and DIGE technology
Proteomics. 2006, 6, 748-56
Terstappen G.C., Gaviraghi G., Caricasole A.
The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.
IDrugs. 2006, 9, 35-8.
Porcari V., Magnoni L., Terstappen G.C., Fecke W.
A continuous time-resolved fluorescence assay for identification of BACE1 inhibitors.
Assay and Drug Development Technologies, 2005, 3, 287-97.
Caricasole A., Bakker A., Copani A., Nicoletti F., Gaviraghi G., Terstappen G.C.
Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology.
Biosci Rep. 2005, 25, 309-27.
Cappuccio I., Calderone A., Busceti C.L., Biagioni F., Pontarelli F., Bruno V., Storto M., Terstappen G.C., Gaviraghi G., Fornai F., Battaglia G., Melchiorri D., Zukin R.S., Nicoletti F., Caricasole A.
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.
J. of Neuroscience 2005, 9, 2647-57.
Kremer A., Schneider R., Terstappen G.C.
A bioinformatics perspective on proteomics: data storage, analysis, and integration.
Biosci Rep. 2005, 25, 95-106.
Raggiaschi R., Gotta S., Terstappen G.C.
Phosphoproteome analysis.
Biosci Rep. 2005, 25, 33-44.
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A., Caruso, A., Storto, M., Gaviraghi, G., Terstappen, G. C. and Nicoletti F.
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer’s brain.
J. of Neuroscience, 2004, 24, 6021-6027
Caricasole, A., Ferraro, T., Iacovelli, L., Barletta, E., Caruso, A., Melchiorri, D., Terstappen G.C. and Nicoletti F.
Functional characterization of Wnt 7a signalling in PC12 cells: Interaction with a FZD5/LRP6 receptor complex and modulation by DKK proteins.
J. Biol. Chem. 2003, 278, 37024-37031
Caricasole, A., Copani, A., Caruso, A., Caraci, F., Iacovelli, L., Sortino, M. A., Terstappen, G.C. and Nicoletti, F.
The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer’s disease? Trends Pharmacol. Sci. 2003, 24, 233-238
(2011)"In Vitro and In Vivo Characterisation of a Novel Hedgehog Signalling Antagonist in Human Glioblastoma Cell Lines", Int. J. Cancer, 20 Dec 2011, Epub ahead of print
Zanelli U., Caradonna N.P., Hallifax D., Turlizzi E., Houston B.J
(2011)" Comparson of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs", Drug Metab Dispos., 13 Oct 2011, Epub ahead of print
Gaviraghi M., Tunici P., Valensin S., Rossi M., Giordano C., Magnoni L., Dandrea M., Montagna L, Ritelli R., Scarpa A., Bakker A.
(2011)"Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells" Biosci Rep. (2011), 31 45-55.
Rossini L., Gianfriddo M., Scali C., Roncarati R., Franceschini D., Pollio G., Terstappen G.C., matsuoka M., Caricasole A.
(2011)" VTSML2 is a novel secreted antagonist of the neuroprotective peptide Humanin", FASEB J (2011) ,25 (6), 1983-2000
Rossi M., Magnoni L., Mori E., Bakker A.,Tini P., Tosi P., Oliveri G., Cosci E., Pirtoli L, Miracco C.
(2011)"beta-catenin and Gli1 as prognostic markers in glioblastoma multiforme", Cancer Biol Ther. (2011), 11(8), 753-61
Marquis K.L., Comery T.A., Jow F. , Navarra R.L., Grauer S.M. , Pulicicchio C., Kelley C., Roncarati R., Scali C., Haydar S., Ghiron C., Harrison B., Terstappen G.C, Dunlop J.
(2011) "Preclinical Assessment of an Adjunctive Treatment Approach for Cognitive Impairment Associated with Schizophrenia Using the Alpha7 Nicotinic Acetylcholine Receptor Agonist WYE-103914" Psychopharmacology (Berl.),218(4), 635-47 (2011)
Del Bello, Fabio; Mattioli, Laura; Ghelfi, Francesca; Giannella, Mario; Piergentili, Alessandro; Quaglia, Wilma; Cardinaletti, Claudia; Perfumi, Marina; Thomas, Russell J.; Zanelli, Ugo; Marchioro, Carla; Dal Cin, Michele; Pigini, Maria
(2010)Fruitful Adrenergic α 2C-Agonism/ α 2A-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence. Journal of Medicinal Chemistry (2010), 53(21), 7825-7835
Gaviraghi, Giovanni
(2010)ß -adrenoceptor agonists and asthma. Analogue-Based Drug Discovery II (2010), 319-331
Robertson G
(2010):Towards a more robust approach to selecting and prosecuting promising targets and compounds. Future Medicinal Chemistry (2010), 2(1), 25-34
Cocconcelli G, Ghiron C, Haydar S, Micco I, Zanaletti R
(2010): Synthesis of Novel 4-Fluoro-2H-pyrazol-3-ylamines. Synthetic Communications (2010), 40(17), 2547-2555.
Galvagni F, Pennacchini S, Salameh A, Rocchigiani M, Neri F, Orlandini M, Petraglia F, Gotta S, Sardone GL, Matteucci G, Terstappen GC, Oliviero S
(2010):Endothelial Cell Adhesion to the Extracellular Matrix Induces c-Src-Dependent VEGFR-3 Phosphorylation Without the Activation of the Receptor Intrinsic Kinase Activity; Circulation Research (2010), 106, 1839-1848
Terstappen, GC, Roncarati R; Dunlop J; Peri R
(2010): Screening technologies for ion channel drug discovery. Future Medicinal Chemistry (2010), 2(5), 715-730.
Ghiron C, Haydar SN, Aschmies S, Bothmann H, Castaldo C, Cocconcelli G, Comery TA, Di L, Dunlop J, Lock T, Kramer A, Kowal D, Jow F, Grauer S, Harrison B, La Rosa S, Maccari L, Marquis KL, Micco I, Nencini A, Quinn J, Robichaud AJ, Roncarati R, Scali C, Terstappen GC, Turlizzi E, Valacchi M, Varrone M, Zanaletti R, Zanelli U.
(2010):Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-103914), Journal of medicinal chemistry Vol. 53 (11): 4379-89
Andersen, Claus A.; Rost, Burkhard
(2009)Secondary structure assignment. Structural Bioinformatics (2nd Edition) (2009), 459-484.
Bakker, A., Caricasole, A., Gaviraghi, G., Pollio, G., Robertson, G., Terstappen, G. C., Salerno, M. and Tunici, P.
(2009): How to achieve confidence in drug discovery and development: managing risk (from a reductionist to a holistic approach), ChemMedChem 4, 923-933
Andersen, C. A., Gotta, S., Magnoni, L., Raggiaschi, R., Kremer, A. and Terstappen, G. C.
(2009): Robust MS quantification method for phosphopeptides using 18O/16O labeling, BMC Bioinformatics 10, 141-156
Palmer, M., Kremer, A. and Terstappen, G. C.
(2009): A primer on screening data management, J. Biomol. Sciences, July 30 [Epub ahead of print]
Fecke, W., Gianfriddo, M., Gaviraghi, G., Terstappen, G. C. and Heitz, F.
(2009): Small molecule drug discovery for Huntington's disease, Drug Discovery Today 14, 453-464
Terstappen, G. C.
(2009):Not a dilemma: Target deconvolution in drug discovery,
Future Medicinal Chemistry , 1, 7-9
Tarditi, A., Caricasole, A. and Terstappen, G. C.
(2009):Therapeutic targets for Alzheimer's disease,
Expert Opinion on Therapeutic Targets , Apr 15 [Epub ahead of print]
Roncarati R., Scali C., Comery TA., Grauer SM., Achmies S., Bothmann H., Jow B., Kowal D., Gianfriddo M., Kelley C., Zanelli U., Ghiron C., Haydar S., Dunlop J., Terstappen, G. C.
(2009):Procognitive and neuroprotective activity of a novel class of alpha7 nicotinic acetylcholine receptor agonists for treatment of neurodegenerative and cognitive disorders
Journal of Pharmacology and Experimental Therapeutics, (epub ahead of print)
Valensin, S., Ghiron, C., Lamanna, C., Kremer, A., Rossi, M., Ferruzzi, P., Nievo, M. and Bakker, A.
(2009):KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain? BMC Cancer 9, 196
Rosi, M. C., Luccarini, I., Grossi, C., Fiorentini, A., Spillantini, M. G., Goedert, M., Prisco, A., Caricasole, A., Terstappen, G. C. and Casamenti, F.
(2009):Increased Dickkopf -1 expression in transgenic mouse models of neurodegenerative disease, J. Neurochem. (Dec 29 [Epub ahead of print])
Pasquini, S., Mugnaini, C., Brizzi, A., Ligresti, A., Di Marzo, V., Ghiron, C. and Corelli F.
(2009):Rapid combinatorial access to a library of 1,5-disubstituted-3-indole-N-alkylacetamides as CB2 receptor ligands, J. Comb. Chem. 11, 795-798
Millucci, L., Raggiaschi, R., Franceschini, D., Terstappen, G. C. and Santucci, A.
(2009):Rapid aggregation and assembly in aqueous solution of Aß (25-35) peptide, J. Biosci. 34, 293-303
Mastroiacovo, F., Busceti, C.L., Biagioni, F., Moyanova, S.G., Meisler, M.H., Battaglia, G., Caricasole, A., Bruno, V. and Nicoletti, F.
(2009):Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia, J. Cereb. Blood Flow Metab. 29, 264-76
Haydar, S.N., Ghiron, C., Bettinetti, L., Bothmann, H., Comery, T.A., Dunlop, J., La Rosa, S., Micco, I., Pollastrini, M., Quinn, J., Roncarati, R., Scali, C., Valacchi, M., Varrone, M. and Zanaletti, R.
(2009):SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist, Bioorg. Med. Chem. 17, 5247-5258
Fantini, M., Rivara, M., Zuliani, V., Kalmar, C.L., Vacondio, F., Silva, C., Baheti, A.R., Singh,N., Merrick, E.C., Katari, R.S., Cocconcelli, G., Ghiron, C., Patel, M.K.
(2009):2,4(5)-diarylimidazoles as inhibitors of hNaV1.2 sodium channels: pharmacological evaluation and structure-property relationships, Bioorg. Med. Chem. 17, 3642-3648
Caraci F, Busceti C, Biagioni F, Aronica E, Mastroiacovo F, Cappuccio I, Battaglia G, Bruno V, Caricasole A, Copani A, Nicoletti F.
The Wnt Antagonist, Dickkopf-1, as a Target for the Treatment of Neurodegenerative Disorders.
Neurochem Res., 2008,33(12):2401-6, Apr 22
Heitz F., La Rosa S., Gonzalez-Couto E., Gaviraghi G. and Terstappen G. C.
Drug discovery and development for Huntington’s disease – an orphan indication with high medical need
IDrugs, 2008, 11, 653-660
Seredenina T., Ferraro T., Terstappen G.C., Caricasole A., Roncarati R.
Molecular cloning and characterization of a novel human variant of RIC-3, a putative chaperone of nicotinic acetylcholine receptors.
Biosci Rep. 2008 Aug 11.
Piras L., Genesio E., Ghiron C., Taddei M.
Scaffold Preparation and Parallel Synthesis of Arrays of 5,6,7,8-Tetrahydropyrrolo-azepinones in the Solution Phase
Eur. J. Org. Chem., 2008, 2789–2800
Micco I., Nencini A., Quinn J., Bothmann H., Ghiron C., Padova A., Papini S.
Parallel synthesis of a series of potentially brain penetrant aminoalkyl benzoimidazoles.
Bioorg Med Chem. 2008, 16, 2313-28
Cocconcelli G., Diodato E., Caricasole A., Gaviraghi G., Genesio E., Ghiron C., Magnoni L., Pecchioli E., Plazzib P.V. and Terstappen G.C.
Aryl azoles with neuroprotective activity—Parallel synthesis and attempts at target identification
Bioorg Med Chem 2008, 16, 2043-52
Pollio G., Hoozemans J.J., Andersen CA, Roncarati R, Rosi MC, van Haastert ES, Seredenina T, Diamanti D, Gotta S, Fiorentini A., Magnoni L., Raggiaschi R., Rozemuller A.J., Casamenti F., Caricasole A., Terstappen G.C.
Increased expression of the oligopeptidase THOP1 is a neuroprotective response to Abeta toxicity
Neurobiol Dis. 2008, 31, 145-58.
Pollio G., Roncarati R., Seredenina T., Terstappen G.C., Caricasole A.
A reporter assay for target validation in primary neuronal cultures
J Neurosci Methods. 2008, 172, 34-7.
Roncarati R., Seredenina T., Jow B., Jow F., Papini S., Kramer A., Bothmann H., Dunlop J., Terstappen G.C..
Functional properties of alpha7 nicotinic acetylcholine receptors co-expressed with RIC-3 in a stable recombinant CHO-K1 cell line.
Assay Drug Dev Technol. 2008, 6, 181-93.
Lamanna C., Bellini M., Padova A., Westerberg G., Maccari L.
Straightforward recursive partitioning model for discarding insoluble compounds in the drug discovery process.
J Med Chem. 2008, 51, 2891-7
Bernocco S., Fondelli C., Matteoni S., Magnoni L., Gotta S., Terstappen G.C., Raggiaschi R.
Sequential detergent fractionation of primary neurons for proteomics studies.
Proteomics, 2008, 8, 930-8.
Piras L., Ghiron C., Minetto G., Taddei M.
Microwave-assisted synthesis of tetrahydroindoles
Tetrahedron Letters, 2008, 49, 459–462
Terstappen, G.C.
Understanding Alzheimer’s disease.
Next Generation Pharmaceutical, 2007, 51-53
Terstappen G.C., Schlüpen C., Raggiaschi R., Gaviraghi G.
Target deconvolution strategies in drug discovery.
Nat Rev Drug Discov. 2007, 6, 891-903.
Dunlop, J., Roncarati, R., Jow, B., Bothmann, H., Lock, T., Kowal, D., Bowlby, M. and Terstappen, G. C.
In vitro screening strategies for nicotinic receptor ligands.
Biochem. Pharmacol. 2007, 74, 1172-1181
Gonzalez Couto E., Matteoni S., Gotta S., Magnoni L., Heitz F., Raggiaschi R., Terstappen G.C. and Kremer A.
Huntington’s Disease: From Experimental Results to Interaction Networks, Patho-Pathway Construction and Disease Hypothesis.
BMC Systems Biology, 2007, 1, 45
Zuliani V., Cocconcelli G., Fantini M., Ghiron C., Rivara M.
A practical synthesis of 2,4(5)-diarylimidazoles from simple building blocks.
J Org Chem. 2007, 72, 4551-3.
Piergentili A., Del Bello F., Gentili F., Giannella M., Quaglia W., Vesprini C., Thomas RJ and Robertson GM.
Solution-phase synthesis of ICG-001, a b-turn peptidomimetic molecule inhibitor of β-catenin–TCF-mediated transcription.
Tetrahedron. 2007, 63, 12912–12916
Magrini R., Bakker A., Gaviraghi G. and Terstappen G.C.
Targeting the p53 tumor suppressor gene function in glioblastomas using small chemical molecules.
Drug Development Research 2006, 67, 790-800
Scali C., Caraci F., Gianfriddo M., Diodato E., Roncarati R., Pollio G., Gaviraghi G., Copani A., Nicoletti F., Terstappen G.C., Caricasole A.
Inhibition of Wnt signaling, modulation of Tau phosphorylation and induction of neuronal cell death by DKK1.
Neurobiol Dis. 2006, 24, 254-65
Caruso A., Motolese M., Iacovelli L., Caraci F., Copani A., Nicoletti F., Terstappen G.C., Gaviraghi G., Caricasole A.
Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.
J Neurochem. 2006, 98, 364-71.
Raggiaschi R., Lorenzetto C., Diodato E., Caricasole A., Gotta S., Terstappen G.C.
Detection of phosphorylation patterns in rat cortical neurons by combining phosphatase treatment and DIGE technology
Proteomics. 2006, 6, 748-56
Terstappen G.C., Gaviraghi G., Caricasole A.
The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders.
IDrugs. 2006, 9, 35-8.
Porcari V., Magnoni L., Terstappen G.C., Fecke W.
A continuous time-resolved fluorescence assay for identification of BACE1 inhibitors.
Assay and Drug Development Technologies, 2005, 3, 287-97.
Caricasole A., Bakker A., Copani A., Nicoletti F., Gaviraghi G., Terstappen G.C.
Two sides of the same coin: Wnt signaling in neurodegeneration and neuro-oncology.
Biosci Rep. 2005, 25, 309-27.
Cappuccio I., Calderone A., Busceti C.L., Biagioni F., Pontarelli F., Bruno V., Storto M., Terstappen G.C., Gaviraghi G., Fornai F., Battaglia G., Melchiorri D., Zukin R.S., Nicoletti F., Caricasole A.
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is required for the development of ischemic neuronal death.
J. of Neuroscience 2005, 9, 2647-57.
Kremer A., Schneider R., Terstappen G.C.
A bioinformatics perspective on proteomics: data storage, analysis, and integration.
Biosci Rep. 2005, 25, 95-106.
Raggiaschi R., Gotta S., Terstappen G.C.
Phosphoproteome analysis.
Biosci Rep. 2005, 25, 33-44.
Caricasole, A., Copani, A., Caraci, F., Aronica, E., Rozemuller, A., Caruso, A., Storto, M., Gaviraghi, G., Terstappen, G. C. and Nicoletti F.
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer’s brain.
J. of Neuroscience, 2004, 24, 6021-6027
Caricasole, A., Ferraro, T., Iacovelli, L., Barletta, E., Caruso, A., Melchiorri, D., Terstappen G.C. and Nicoletti F.
Functional characterization of Wnt 7a signalling in PC12 cells: Interaction with a FZD5/LRP6 receptor complex and modulation by DKK proteins.
J. Biol. Chem. 2003, 278, 37024-37031
Caricasole, A., Copani, A., Caruso, A., Caraci, F., Iacovelli, L., Sortino, M. A., Terstappen, G.C. and Nicoletti, F.
The Wnt pathway, cell-cycle activation and β-amyloid: novel therapeutic strategies in Alzheimer’s disease? Trends Pharmacol. Sci. 2003, 24, 233-238
