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Cell
signaling processes regulate fundamental
cellular responses and their dysregulation
can lead to the development of various
human diseases including cancer. Protein
tyrosine phosphorylation is a reversible,
dynamic process controlled by the activities
of protein tyrosine kinases (PTKs) and
protein tyrosine phosphatases (PTPs)
which governs a diverse range of cellular
responses including growth, proliferation,
differentiation, migration, metabolism
and survival.
Thus, individual PTPs might represent
important targets for therapeutic intervention.
The development of small molecule modulators
of these enzymes will further the understanding
of their role in cancer-relevant cellular
processes such as proliferation, division
and migration and should also lead to
effective treatment of brain tumours. |
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