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Diseases
affecting the brain's ability to function
have a devastating impact on our self-consciousness
and our capacity to interact with our
fellow human beings and the environment
at large. Neurons can die due to the
loss of blood supply, for example following
accidental trauma or after a stroke.
More commonly, neuronal death in the
brain can occur as a result of neurodegenerative
processes associated with aging and
with genetic disease. Siena Biotech is
committed to the discovery of novel
approaches aimed at interfering with
neuronal degeneration and death, with
the objective of providing mechanistic
insights into disease and opportunities
for new therapeutic strategies.
To this end, a variety of neuronal cell
models (cell lines and primary neuronal
cultures) are being analysed at the
cellular and molecular level in order
to elucidate the events underlying degenerative
disease. In these systems, the analysis
of gene expression at the RNA and protein
level and of gene function using standard
biochemical/molecular approaches, confocal
microscopy and reporter gene technology,
will be employed to identify and validate
targets of relevance to CNS disease.
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