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Huntington’s
Disease (HD) is a rare inherited
neurodegenerative disorder sometimes
also referred to as Huntington's chorea.
The greek word chorea means "dance"
and refers to the characteristic movement
disorder that is part of the illness.
The genetic origin of HD was already
recognized in the first description
of the Disease in 1872 and the Disease
gene (huntingtin, htt) identified in
1993. HD is caused by an insertion of
CAG repeats in the huntingtin gene but
it is not completely clear how mutated
Htt mediates toxicity. A Disease-modifying
therapy is not available yet.
HD Research
An exploratory research program in collaboration
with the University of Cambridge (UK)
elucidates Htt-mediated pathological
mechanism(s) in a systematic manner.
The aim of this program is to further
the understanding of Htt-mediated toxicity
which should lead to novel targets for
therapeutic intervention. The scope
of another research program is the identification
of inhibitors of Htt-mediated toxicity
for pharmacological therapy. |
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