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Our approaches to finding
hits against targets of interest are
centred on efficient utilization of
available data, utilizing available
active site information and/or known
ligand structures as shown below.
Focussed compound arrays are thus used
to generate hit compounds suitable for
initial exploration of targets of interest.
All compounds are profiled against a
selection of in vitro physicochemical
and ADMET screens, such as solubility,
metabolic stability, and passive permeability,
to ensure that all compounds can be
progressed simultaneously for biological
and molecular property optimization.
Early stage screening of all compounds
through physicochemical and ADMET screens
will afford a wide chemical space for
data-mining and in silico approaches
and help development of models and experience
for ADMET properties. |
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