Siena Biotech is located in Siena in a science park on the outskirts of the city, active since the beginning of last century, which is the location of Novartis, the University of Siena and the Toscana Life Sciences Park as well.

The Discovery Research Division operates in an historical building located on campus.

Corporate offices, the Finance & Business Development Division and the Therapeutic Research Division are located in another newly refurbished building.